Systemic immunosuppressive agents are recommended for patients with atopic eczema in whom disease activity cannot be controlled adequately with topical treatments. Guidelines do not give clear advice which agents to prefer. We systematically reviewed clinical trials on systemic treatment for severe atopic eczema to provide evidence-based treatment recommendations. Standardized literature search...

The achievements in photoimmunology over the last years have not only broadened our knowledge how ultraviolet (UV) light compromises the immune system but have also yielded important insights into general immunology and photobiology. Therefore, studies will not only increase our understanding how UV acts as a pathogen but will also support the development of new therapeutic strategies, e.g. sup...

background: the purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (mpa) in iranian kidney transplant patients. methods: plasma mpa concentration of mycophenolate mofetile (mmf) 1 gram two times a day was measured in 21 iranian kidney transplant recipients receiving treatment. patients who entered the study had been transplanted for more than 3 months ...

introduction : recipients of renal transplants are susceptible to kaposi's sarcoma (ks) as a result of treatment with immunosuppressive drugs. ks is one of the most common post transplant malignancies. variety of factors appear to contribute to the development of ks including: genetic factors, sex hormones, immunosuppression and oncogenic viruses.this study present three cases of renal transpla...

BACKGROUND End-stage liver diseases are common in Iran. The only therapeutic option for these patients is liver transplantation. OBJECTIVE To present our 2-year experience of liver transplantations in Afzalipoor Hospital, Kerman, southeastern Iran. METHODS From November 2009 to September 2011, 12 patients underwent orthotopic liver transplantation in our center. Their data including demogra...

BACKGROUND Immunosuppressive drugs have been used in the treatment of multiple sclerosis (MS) for a long time. Today, orally available second generation immunosuppressive agents have been approved or are filed for licensing as MS therapeutics. Due to semi-selective targeting of cellular processes, these second-generation immunosuppressive compounds might rather be immunomodulatory. For example,...

In vivo T-cell depletion might contribute to the delayed immune reconstitution observed after unrelated umbilical cord blood transplantation (UCBT). We studied the impact of early, late, and no antithymocyte globulin (ATG) on immune reconstitution and outcome. One hundred twenty seven children receiving UCBT in London or Utrecht were divided into 3 groups: early ATG (days -9 to -5; n = 33), lat...